Hundreds of protesters battled police in the heart of Barcelona amid anger over the jailing of Catalan separatist leaders.
Masked protestors were seen blocking areas, damaging police vehicles, setting fire to large garbage bins, ransacking banks and attacking riot police officers with stones, cans and bottles.
Police responded with repeated volleys of foam bullets, smoke grenades, tear gas and water cannons.
The violence followed a largely peaceful demonstration that drew more than half a million people onto the streets of the Catalan capital.
Catalan interior affairs chief Miquel Buch distanced themselves from the riots, claiming "this kind of violence is unprecedented in Catalonia ... these people are not separatists".
Some 128 people have been arrested in the region over the past five days, with Spain's acting interior minister, Fernando Grande-Marlaska, warning that rioters faced up to six years in prison.
The climate crisis and an unlimited expansion of artificial intelligence could be existential threats for humanity, United Nations Secretary-General Antonio Guterres said on Wednesday, adding AI should serve humanity and not the other way around.
Prince Harry claimed a "monumental" victory over Rupert Murdoch's UK newspaper group on Wednesday after the publisher settled his lawsuit, admitting unlawful actions at its Sun tabloid for the first time and paying substantial damages.
US President Donald Trump has pardoned Silk Road founder Ross Ulbricht, who was sentenced to life in prison for running an underground online marketplace where drug dealers and others conducted more than $200 million in illicit trade using bitcoin.
Israeli security forces backed by helicopters raided the volatile West Bank city of Jenin on Tuesday, killing at least nine Palestinians in what Prime Minister Benjamin Netanyahu called a, "large-scale and significant military operation".
Ras Al-Khaimah Police have seized AED27.5 million ($7.5 million) in counterfeit currency after receiving a tip-off that it was going to be distributed into circulation.